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Sandwich ELISA Kit for the quantitative measurement of Cyclophilin B, also known as Peptidyl-prolyl cis-trans isomerase B, PPIase B, CYP-S1, Rotamase B, S-cyclophilin, SCYLP, PPIB, CYPB in Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate samples.
CypB acts in progression of inflammatory diseases such as rheumatoid arthritis and psoriasis, but is equally involved in the first steps of certain viral infections. Its inflammatory activity is conditioned by its interaction with heparan sulfate proteoglycans and the membrane receptor CD147, two binding partners at the cell surface of T cell lymphocytes, granulocytes and macrophages. CypB is able to induce chemotaxis and triggers T lymphocyte adhesion to fibronectin in the extracellular matrix. Cyclophilin B is closely associated with the occurrence and progression of tumors. This protein has been shown to be highly expressed in breast, liver, colon, stomach and pancreatic cancer.
İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Oncology.
Sandwich ELISA Kit for the quantitative measurement of Secretoglobin 3A2, also known as Pneumo secretory protein 1, PnSP-1, Uteroglobin-related protein 1
in Amniotic fluid, Bronchoalveolar lavage, Plasma (EDTA, citrate, heparin), Serum samples.
İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Oncology, Pulmonary diseases.
Secretoglobin 3A2 (Secretoglobin family 3A member 2; gene scgb3A2; synonym: uteroglobin-related protein 1, UGRP1) is a homodimeric secretory protein thought to play a role in the modulation of inflammation and tumorigenesis. SCGB3A2 has been shown as a potentially useful marker for diagnosis of pulmonary tumours both in mice and humans.
Capture ELISA Kit for the quantitative measurement of Anti-Alpha-Galactosyl IgE (Human) ELISA Kit (anti-α-Gal IgE) in Serum samples.İlgili Araştırma Alanları: Immunology, Allergology, Immune Response, Biological Therapy, Oncology
Although IgM, IgA and IgG antibodies to α-Gal (anti-α-Gal or anti-Gal) are widely expressed in humans, IgE anti-α-Gal antibodies are not. There is now extensive evidence that the primary impulse to start production of these IgE antibodies is a tick bite or parasitic infestation. The association between tick bites, red meat allergy and IgE to alpha-Gal has been reported from four continents to date
Sandwich ELISA Kit for the quantitative measurement of Active Renin, also known as Angiotensinogenase in Amniotic fluid, Plasma (EDTA, citrate, heparin), Serum and Urine samples.
İlgili Araştırma Alanları: Atherosclerosis, Cardiovascular disease, Diabetes, Hypertension, Renal Disease
Renin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS), which primarily acts to control blood pressure and sodium balance. RAAS activity is also involved in angiogenesis, cellular growth, fibrosis, reproduction, inflammation, immunity, intracellular redox balance and antidiuretic hormone production.
Measurement of plasma active renin is important for differential diagnosis of hypertension, clinical assessment of hypertensive patients and for diagnostics of insufficient response to antihypertensive treatment.
Sandwich ELISA Kit for the quantitative measurement of Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14) in serum, plasma (citrate, heparin, EDTA) and cell culture supernatant samples.
İlgili Araştırma Alanları :Immune Response
HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. Recent studies have shown HVEM as a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
Sandwich ELISA Kit for the quantitative measurement of ATPase Inhibitory Factor 1 (IF1) / ATPase Inhibitor Mitochondrial in Plasma (EDTA, citrate, heparin), Serum, Tissue extract samples.
İlgili Araştırma Alanları :Oncology
It is concluded that the low ATPase activity of the tumor mitochondria results from the inhibition of the enzyme activity by the natural ATPase inhibitor. Recent study reported that reciprocal activation between IF1 and nuclear factor NF-κB promoted HCC angiogenesis and metastasis. In colon cancer cells, IF1 promoted aerobic glycolysis and reactive oxygen species-mediated signaling pathway to enhance cell proliferation and cell survival. IF1 may promote tumor progression by promoting migration and invasion in glioma cells.
Sandwich ELISA Kit for the quantitative measurement of PCSK9 in in cell culture supernates, cell lysates, serum, and plasma samples.
İlgili Araştırma Alanları : Lipid and Energy Metabolism, Cardiovascular Diseases
PCSK9 regulates the amount of LDL R in the circulation and modulates cholesterol levels. Serum PCSK9 concentrations have been found to be directly associated with cholesterol levels. Since individuals with loss-of-function PCSK9 mutations have strikingly reduced risk of coronary heart diseases, PCSK9 has become an attractive drug target in recent years.
Sandwich ELISA Kit for the quantitative measurement of human TIM-3 (T-cell immunoglobulin and Mucin-domain Containing-3) in Serum, plasma (citrate, heparin, EDTA) and cell culture supernatant.
TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) or HAVCR2, is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It regulates macrophage activation. It is also an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity.
Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. Furthermore, the immune checkpoint receptor TIM-3 exhibits several unique features that make it an intriguing candidate for the next wave of therapies that target immune checkpoints in cancer.
Sandwich ELISA Kit for the quantitative measurement of human peripheral blood B and T lymphocyte attenuator (BTLA) in Serum, plasma (citrate, heparin, EDTA) and cell culture supernatant samples.
İlgili Araştırma Alanları: Antitumour Immunity, Oncology.
BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in the thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA has been implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It was shown that dual blockade of BTLA and PD1 enhances antitumour immunity.
Sandwich ELISA Kit for the quantitative measurement of Survivin in cell culture supernatants, plasma, serum, and urine samples.
İlgili Araştırma Alanları: Oncology.
Survivin is dramatically over-expressed in many cancers and the expression in these tumors can correlate with an increased rate of tumor recurrence and resistance to therapy.
The presence of Survivin in urine may also act as a marker for bladder cancer. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients
Sandwich ELISA Kit for the quantitative measurement of human Kallistatin / Serpin A4; Kallikrein inhibitor; Peptidase inhibitor 4 in human Amniotic fluid, Bronchoalveolar lavage, Cerebrospinal fluid, Milk, Plasma (EDTA, citrate, heparin), Serum, Urine samples.
Sandwich ELISA Kit for the quantitative measurement of human Activin A in serum and plasma samples.
ELISA Kit (Sandwich ELISA, Biotin-labelled antibody) for the quantitative measurement of suPAR in Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum, Urine samples.
Diğer İsimleri: Soluble Plasminogen Activator Urokinase Receptor, Soluble Urokinase-Type Plasminogen Activator Receptor, Soluble uPAR, sPLAUR
İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Renal disease
Elevated levels of suPAR in circulation are considered to be a marker for activation of immune and inflammatory systems. In the acute setting, elevated levels of suPAR have been proposed to be predictive for disease severity in bacteraemia, human immunodeficiency virus infection (HIV), bacterial meningitis, active pulmonary tuberculosis, ventilator-associated pneumonia with sepsis, and in intensive care unit (ICU) patients with or without sepsis. The suPAR was also discovered as a cause of chronic renal disease focal segmental glomerulosclerosis.
ELISA Kit for the quantitative measurement of human Shh-N in cell culture supernates, serum, and heparin plasma samples
Diğer İsimleri :Sonic Hedgehog Homolog, Sonic Hedgehog Protein, TPT, TPTPS
İlgili Araştırma Alanları: Hedgehog Family, Neuronal Migration, Development of Central Nervous System.
Sandwich ELISA Kit for the quantitative measurement human Collagen triple helix repeat-containing protein 1 (CTHRC1) in Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum, Tissue extract samples.
İlgili Araştırma Alanları: Atherosclerosis, Bone and cartilage metabolism, Cardiovascular disease, Coronary artery disease, Energy metabolism and body weight regulation, Oncology
The results indicate that CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis. CTHRC1 could serve as a potential marker for predicting progression and metastasis of the aforementioned types of cancers.
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