Yeni Ürünler - Meditek R&D|ELISA Araştırma Kitleri|Flow Sitometri-IHC Antikorları

Yeni Ürünler : Yeni Biyolojik Markerlar için ELISA Araştırma Kitleri

 

Immunoassay ELISA Kit

 

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Yeni biyomarkerları yakından takip ediyor ve çalışmalarınızın hedef biyomarkerları için belirlediğiniz yöntemlere  uygun ELISA Kitleri, Antikorlar (Immünohistokimya ve Flow Sitometri), Aktivite Ölçüm Kitleri ve Rekombinant Proteinler sunuyoruz.
 
 

 

 

► Cyclophilin B Human ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Cyclophilin B, also known as Peptidyl-prolyl cis-trans isomerase B, PPIase B, CYP-S1, Rotamase B, S-cyclophilin, SCYLP, PPIB, CYPB in Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate samples.

CypB acts in progression of inflammatory diseases such as rheumatoid arthritis and psoriasis, but is equally involved in the first steps of certain viral infections. Its inflammatory activity is conditioned by its interaction with heparan sulfate proteoglycans and the membrane receptor CD147, two binding partners at the cell surface of T cell lymphocytes, granulocytes and macrophages. CypB is able to induce chemotaxis and triggers T lymphocyte adhesion to fibronectin in the extracellular matrix. Cyclophilin B is closely associated with the occurrence and progression of tumors. This protein has been shown to be highly expressed in breast, liver, colon, stomach and pancreatic cancer.

İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Oncology.

 

► Secretoglobin 3A2 / SCGB3A2 (Human) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Secretoglobin 3A2, also known as Pneumo secretory protein 1, PnSP-1, Uteroglobin-related protein 1
in Amniotic fluid, Bronchoalveolar lavage, Plasma (EDTA, citrate, heparin), Serum samples.

İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Oncology, Pulmonary diseases.

Secretoglobin 3A2 (Secretoglobin family 3A member 2; gene scgb3A2; synonym: uteroglobin-related protein 1, UGRP1) is a homodimeric secretory protein thought to play a role in the modulation of inflammation and tumorigenesis. SCGB3A2 has been shown as a potentially useful marker for diagnosis of pulmonary tumours both in mice and humans.

 

 

► Anti-Alpha-Galactosyl IgE (Human) ELISA Kit:

Capture ELISA Kit for the quantitative measurement of Anti-Alpha-Galactosyl IgE (Human) ELISA Kit (anti-α-Gal IgE) in Serum samples.

İlgili Araştırma Alanları: Immunology, Allergology, Immune Response, Biological Therapy, Oncology

Although IgM, IgA and IgG antibodies to α-Gal (anti-α-Gal or anti-Gal) are widely expressed in humans, IgE anti-α-Gal antibodies are not. There is now extensive evidence that the primary impulse to start production of these IgE antibodies is a tick bite or parasitic infestation. The association between tick bites, red meat allergy and IgE to alpha-Gal has been reported from four continents to date

 

► Active Renin ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Active Renin, also known as  Angiotensinogenase in Amniotic fluid, Plasma (EDTA, citrate, heparin), Serum and Urine samples.

İlgili Araştırma Alanları: Atherosclerosis, Cardiovascular disease, Diabetes, Hypertension, Renal Disease
 

Renin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS), which primarily acts to control blood pressure and sodium balance. RAAS activity is also involved in angiogenesis, cellular growth, fibrosis, reproduction, inflammation, immunity, intracellular redox balance and antidiuretic hormone production.

Measurement of plasma active renin is important for differential diagnosis of hypertension, clinical assessment of hypertensive patients and for diagnostics of insufficient response to antihypertensive treatment.

 

► Human Herpesvirus Entry Mediator (HVEM) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14) in serum, plasma (citrate, heparin, EDTA) and cell culture supernatant samples.

İlgili Araştırma Alanları :Immune Response

HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. Recent studies have shown HVEM as a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.

 

► ATPase Inhibitory Factor 1 (IF1) / ATPase Inhibitor Mitochondrial ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of ATPase Inhibitory Factor 1 (IF1) / ATPase Inhibitor Mitochondrial in Plasma (EDTA, citrate, heparin), Serum, Tissue extract samples.

İlgili Araştırma Alanları :Oncology

It is concluded that the low ATPase activity of the tumor mitochondria results from the inhibition of the enzyme activity by the natural ATPase inhibitor. Recent study reported that reciprocal activation between IF1 and nuclear factor NF-κB promoted HCC angiogenesis and metastasis. In colon cancer cells, IF1 promoted aerobic glycolysis and reactive oxygen species-mediated signaling pathway to enhance cell proliferation and cell survival. IF1 may promote tumor progression by promoting migration and invasion in glioma cells.

 

 

► Human Proprotein Convertase 9/Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of PCSK9 in in cell culture supernates, cell lysates, serum, and plasma samples.

İlgili Araştırma Alanları : Lipid and Energy Metabolism, Cardiovascular Diseases

PCSK9 regulates the amount of LDL R in the circulation and modulates cholesterol levels. Serum PCSK9 concentrations have been found to be directly associated with cholesterol levels. Since individuals with loss-of-function PCSK9 mutations have strikingly reduced risk of coronary heart diseases, PCSK9 has become an attractive drug target in recent years.

 

 

► Azurocidin /Heparin-Binding Protein (HBP) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Azurocidin, also known as cationic antimicrobial protein 37 kDa (CAP37) or heparin-binding protein (HBP) in Plasma (EDTA, citrate, heparin), Serum, Urine samples.
 
İlgili Araştırma Alanları : Immune Response, Infection and Inflammation, Sepsis
 
Azurocidin is promising biomarker for identification of patients who are at risk in developing sepsis. Plasma HBP levels correlate with the severity of infection and, in particular, with the development of circulatory failure. There is close correlation between increased HBP plasma levels and the development of hypotension, organ failure, and septic shock. Due to its antimicrobial features, elevated cerebrospinal fluid levels of HBP distinguish between patients with acute bacterial meningitis and patients with other central nervous system infections.
 
 

► Human TIM-3 (T-cell immunoglobulin and Mucin-domain Containing-3) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human TIM-3 (T-cell immunoglobulin and Mucin-domain Containing-3) in Serum, plasma (citrate, heparin, EDTA) and cell culture supernatant.

TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) or  HAVCR2, is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It regulates macrophage activation. It is also an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity.

Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. Furthermore, the immune checkpoint receptor TIM-3 exhibits several unique features that make it an intriguing candidate for the next wave of therapies that target immune checkpoints in cancer.

 

 

► BTLA (Human) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human peripheral blood B and T lymphocyte attenuator (BTLA) in Serum, plasma (citrate, heparin, EDTA) and cell culture supernatant samples.

İlgili Araştırma Alanları:  Antitumour Immunity, Oncology.

BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in the thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA has been implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It was shown that dual blockade of BTLA and PD1 enhances antitumour immunity.

 

► Human Survivin ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of Survivin in cell culture supernatants, plasma, serum, and urine samples.

İlgili Araştırma Alanları:  Oncology.

Survivin is dramatically over-expressed in many cancers and the expression in these tumors can correlate with an increased rate of tumor recurrence and resistance to therapy.
The presence of Survivin in urine may also act as a marker for bladder cancer. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients

 

 

► Betatrophin (Mouse) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of mouse Betatrophin / Angiopoietin-Like Protein-8 (ANGPTL8), Lipasin in serum samples.
 
İlgili Araştırma Alanları:  Diabetology -Energy metabolism and body weight regulation, Lipoprotein metabolism.
 
ANGPTL8 (Betatrophin) is involved in lipid metabolism. ANGPTL8 plays a major role in the trafficking of triglycerides to peripheral tissues in response to food intake in mice. The secreted protein has been detected in human plasma. Plasma betatrophin concentrations are approximately doubled in patients with type 1 diabetes. Betatrophin is 40% higher in patients with type 2 diabetes and levels increase with age. The recent discovery of betatrophin has raised high hopes for the rapid development of a novel therapeutic approach for the treatment of diabetes. At present, however, the effects of betatrophin on human β-cells are not known. Although mouse β-cells, in their normal location in the pancreas or when transplanted under the kidney capsule, respond with a dramatic increase in β-cell DNA replication, human β-cells are completely unresponsive. These results put into question whether betatrophin could be useful with respect to treating human diabetes.
 
 

► Glucocorticoid-induced TNFR-Related Protein (GITR) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Glucocorticoid-induced TNFR-related protein (GITR) in cell culture supernatant, serum, plasma (EDTA, citrate, heparin) samples.
 
İlgili Araştırma Alanları:  Apoptosis, Immune Response, Oncology.
 
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the tumor necrosis factor receptor (TNF-R) and is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18). GITR plays role in activation of NF-kappa-B via the TRAF2/NIK pathway. It has been shown that antibodies to GITR promote an anti-tumor response through loss of Treg lineage stability.
 
 

► Lymphocyte-Activation Gene 3 (LAG3) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Lymphocyte-Activation Gene 3 (LAG3) in cell culture supernatant, serum, plasma (EDTA, citrate, heparin) samples.
 
İlgili Araştırma Alanları:  Immune Response, Oncology.
 
Lymphocyte-activation gene 3 also known as LAG-3 or CD223 is a cell surface molecule and has diverse effects on T cells, NK cells, B cells and dendritic cells. LAG-3 is an immune checkpoint marker  involved in various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
 
 

► Kallistatin / Serpin A4 (Human) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Kallistatin / Serpin A4; Kallikrein inhibitor; Peptidase inhibitor 4 in human Amniotic fluid, Bronchoalveolar lavage, Cerebrospinal fluid, Milk, Plasma (EDTA, citrate, heparin), Serum, Urine samples.

İlgili Araştırma Alanları: Cardiovascular Disease, Diabetology, Immune Response, Infection and Inflammation, Oncology.
 
Kallistatin (Kallikrein-Binding Protein – KBP, Serpin A4) has multiple biologic functions independent of the tissue kallikrein-kinin system and exhibits pleiotropic effects in vasodilation, inhibition of inflammation, angiogenesis, fibrosis, apoptosis, oxidative stress and cancer progression. Kallistatin is reported to be a reliable biomarker for the diagnosis of liver cirrhosis.
 
 
 

► 6-Phosphogluconate Dehydrogenase (6PGDH) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human 6-Phosphogluconate Dehydrogenase (6PGDH) in Cerebrospinal fluid, Plasma (EDTA, citrate, heparin), Serum, Urine.
 
İlgili Araştırma Alanları: Cardiovascular Disease, Oncology.
 
Recent study indicates that knockdown of 6-phosphogluconate dehydrogenase inhibits growth of lung cancer cells by senescence induction.
 
 
 

► Programmed T cell death ligand 1 (PD-L1) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human CD274 / Cluster of Differentiation 274 / Programmed Cell Death Protein 1 Ligand / PD-L1 1 in serum, plasma (citrate, heparin, EDTA) and cell culture supernatant samples.
 
İlgili Araştırma Alanları: Onkoloji, İmmunoloji.
 
The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion and PD-L1 is reported to be a Predictive Biomarker for  Cancer. The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell activation and is also an important therapeutic target for autoimmune diseases.
 
 

► Stanniocalcin 1 ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Stanniocalcin 1 in Milk, Plasma (EDTA, citrate, heparin), Serum, Urine samples.
 
İlgili Araştırma Alanları: Kemk ve Kıkırdak Metabolizması,  Onkoloji.
 
Stanniocalcin 1 upregulation play an important role in gastric cancer development and serum STC1 might function as promising tumor marker for gastric cancer diagnosis and prognosis. STC1 can affect bone and muscle mass and structure, and angiogenesis through effects on osteoblasts, osteoclasts, myoblasts/myocytes, and endothelial cells.
 
 

► Activin-A (Human) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Activin A in serum and plasma samples.

Diğer İsimleri: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-Releasing Protein
 
İlgili Araştırma Alanları: Apoptosis, Cardiovascular disease, Neural tissue markers, Oncology.
 
Activin A  is a member of the TGF-β super family and plays an important role in oogenesis and folliculogenesis. Activin A also has a wide range of biological activities including regulation of cellular proliferation and differentiation, apoptosis, and promotion of neuronal survival.
 
 
 

► Human Gastrokine-1 ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement of human Gastrokine-1 in Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum samles.
 
Diğer İsimleri: 18 kDa antrum mucosa protein, AMP-18, CA11, GKN1, AMP18
 
Gastrokine-1 plays an important role in epithelial-mesenchymal transition and migration of gastric cancer cells by regulating reactive oxygen species (ROS) and the P13K/Akt pathway. Recent studies suggest  Gastrokine-1 acts as a gastric-specific tumor suppressor.
 
 

► Regenerating Islet Derived Protein 4 (REG4) ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement human Regenerating Islet Derived Protein 4 in human serum and plasma samples.
 
Diğer İsimleri: Gastrointestinal secretory protein, REG-like protein, Regenerating islet-derived protein IV
 
İlgili Araştırma Alanları: Oncology; REG4 is reported to be a potential biomarker for ovarian cancer.
 
 
 

► Aminoacylase-1 ELISA Kit:

Sandwich ELISA Kit for the quantitative measurement human Aminoacylase-1 in Plasma-Citrate, Plasma-Heparin, Serum, Urine samples
 
Diğer İsimleri: ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1
 
The expression of Aminoacylase-1 is highest in the kidney and brain. Aminoacylase-1 is a potential biomarker of long-term outcome after kidney transplantation.
 
ACY-1 plays a role in regulating responses of the cell to oxidative stress. ACY-1 serves as a putative suppressor in renal cell carcinoma and small cell lung cancer. ACY-1 expression is also significantly correlated with serum alpha fetoprotein level and tumor invasiveness. It was also demonstrated that ACY-1 acts as a tumor suppresor in hepatocellular carcinoma.
 
 
 

Soluble Urokinase Plasminogen Activator Receptor (suPAR) ELISA Kit:

ELISA Kit (Sandwich ELISA, Biotin-labelled antibody) for the quantitative measurement of suPAR in Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum, Urine samples.

Diğer İsimleri: Soluble Plasminogen Activator Urokinase Receptor, Soluble Urokinase-Type Plasminogen Activator Receptor, Soluble uPAR, sPLAUR

İlgili Araştırma Alanları: Immune Response, Infection and Inflammation, Renal disease

Elevated levels of suPAR in circulation are considered to be a marker for activation of immune and inflammatory systems. In the acute setting, elevated levels of suPAR have been proposed to be predictive for disease severity in bacteraemia, human immunodeficiency virus infection (HIV), bacterial meningitis, active pulmonary tuberculosis, ventilator-associated pneumonia with sepsis, and in intensive care unit (ICU) patients with or without sepsis. The suPAR was also discovered as a cause of chronic renal disease focal segmental glomerulosclerosis.

 

 

Human Sonic Hedgehog/Shh N-Terminus ELISA Kit: 

ELISA Kit for the quantitative measurement of human Shh-N in cell culture supernates, serum, and heparin plasma samples

Diğer İsimleri :Sonic Hedgehog Homolog, Sonic Hedgehog Protein, TPT, TPTPS

İlgili Araştırma Alanları: Hedgehog Family, Neuronal Migration, Development of Central Nervous System.

 

 

Collagen Triple Helix Repeat-Containing Protein 1 (CTHRC1): 

Sandwich ELISA Kit for the quantitative measurement human Collagen triple helix repeat-containing protein 1 (CTHRC1) in Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum, Tissue extract samples.

İlgili Araştırma Alanları: Atherosclerosis, Bone and cartilage metabolism, Cardiovascular disease, Coronary artery disease, Energy metabolism and body weight regulation, Oncology

The results indicate that CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis. CTHRC1 could serve as a potential marker for predicting progression and metastasis of the aforementioned types of cancers.

 

 

 

 

 

 

 
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